Spontaneous mutation rate
نویسندگان
چکیده
منابع مشابه
Spontaneous mutation rate in retinoblastoma.
A novel approach was used to estimate the in vivo mutation rate of the retinoblastoma gene. A mathematical formula can be used to calculate the probability of neoplasia induced by one or more mutations in a population of dividing cells. This formula can then be applied to epidemiological data on hereditary and sporadic retinoblastoma. The analysis yields an estimate of the in vivo mutation rate...
متن کاملSpontaneous mutation rate in the dumpy region of Drosophila.
PONTANEOUS mutational events have been examined at a number of differs ent loci in Drosophila and the one consistent observation in all studies is the variability in mutation rates at the various loci. This study reports the spontaneous mutation frequency of the dumpy region ( d p , 2,13 i. ) in Drosophila to be at least three times greater than for any other gene studied in Drosophila, and cou...
متن کاملThe rate and character of spontaneous mutation in Thermus thermophilus.
Selection of spontaneous, loss-of-function mutations at two chromosomal loci (pyrF and pyrE) enabled the first molecular-level analysis of replication fidelity in the extremely thermophilic bacterium Thermus thermophilus. Two different methods yielded similar mutation rates, and mutational spectra determined by sequencing of independent mutants revealed a variety of replication errors distribut...
متن کاملThe Spontaneous Mutation Rate in the Fission Yeast Schizosaccharomyces pombe.
The rate at which new mutations arise in the genome is a key factor in the evolution and adaptation of species. Here we describe the rate and spectrum of spontaneous mutations for the fission yeast Schizosaccharomyces pombe, a key model organism with many similarities to higher eukaryotes. We undertook an ∼1700-generation mutation accumulation (MA) experiment with a haploid S. pombe, generating...
متن کاملLtter Estimation of the Spontaneous Mutation Rate in Heliconius melpomene
We estimated the spontaneous mutation rate in Heliconius melpomene by genome sequencing of a pair of parents and 30 of their offspring, based on the ratio of number of de novo heterozygotes to the number of callable site-individuals. We detected nine new mutations, each one affecting a single site in a single offspring. This yields an estimated mutation rate of 2.9 10 9 (95% confidence interval...
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ژورنال
عنوان ژورنال: Nature
سال: 1991
ISSN: 0028-0836,1476-4687
DOI: 10.1038/352200a0